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I wanted to add DSR line to my USB to TTL programmer. it is based on the PL2303 and it quite easy to do . After the modification you will be able to program the Arduino without having to hold the Reset button.
 
This is the front view of the device:




This is the back  view of the device:


 There is this 3.3V extra pin that we don't need , Let convert it to DTR line. 
The DTR line reside on pin number 2, we'll make a jumper , right after we cut the 3.3V trace.
The 100nF need to be in series with the DTR output to generate the right timing for the Arduino ,we can recycle the coupling capacitor for this.

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